Beilstein J. Org. Chem.2010,6, No. 24, doi:10.3762/bjoc.6.24
)neuraminic acid (Neu5Hex) into the cell-surface glycocalyx of a human larynx carcinoma cell line (HEp-2) and its fluorescence labelling by click chemistry.
Keywords: bioorthogonalmetabolicglycoengineering; click chemistry; sialic acid; Introduction
The surface of eukaryotic cells is heavily covered with
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Graphical Abstract
Scheme 1:
The natural forms of sialic acids, human N-acetylneuraminic acid (Neu5Ac, 1) and mammalian N-glycol...